Kristian Thorsen

Associate Professor

Kristian Thorsen

Contact

Telephone: 51832056

Email: kristian.thorsen@uis.no

Room: KE E-440

Department

Faculty of Science and Technology

Department of Electrical Engineering and Computer Science

About me

Kristian Thorsen is an Associate Professor in Control Engineering at the University of Stavanger (UiS), Norway. He is currently the leader of the Cybernetics and Systems Biology Laboratories research group.

Teaching and research interests

Cybernetics, dynamic systems, systems biology, synthetic biology, nonlinear systems, control engineering, control theory, mathematical modeling, electronics, embedded systems, signal processing, automation, robotics.

My interest in teaching comes from my own enthusiasm for science and engineering. In my approach to teaching I seek to combine a thorough understanding of theory, facts, and logic reasoning with practical applications and solving of industry relevant problems. I prefer to give courses that bring students into an engineering culture.

My research is focused on using concepts from control engineering to understand regulation in biological systems and on using mathematical models to understand and predict biological phenomena in single cells and in populations of cells and their environment.

ResearchGate profile: https://www.researchgate.net/profile/Kristian_Thorsen
Google Scholar profile: https://scholar.google.no/citations?user=JBSSvZIAAAAJ
Research group page: https://www.uis.no/en/cybernetics-and-systems-biology-laboratories
Full academic CV: Dropbox Link

Teaching experience
ELE340 Embedded design / Computer design (10 ECTS)
Offered in the fifth semester of the bachelor’s degree in electrical engineering. This course gives insight into structured design of embedded systems, i.e., microprocessor-based systems for measurement and control. The students are organized into project groups and project management and a multidiscipline attitude is emphasized. Design exercises in the laboratory forms a main part of the course. Full description: https://www.uis.no/en/course/ELE340_1
Autumn 2016 – 2019, 2020*, 2021 (planned).
ELE600 Advanced control systems and robotics (10 ECTS)
Offered in the second semester of the master’s degree in control engineering. This course deals with feedback control systems, stability analysis, control parameter settings, gain scheduling, cascade control, feed forward control, deadtime compensation and multivariable control. In addition, basic robotic technology, coordinate systems, the Denavit-Hartenberg convention, forward and inverse kinematics, and the use of feedback control for positioning and velocity control of robotic joints. Full description: https://www.uis.no/en/course/ELE600_1
Spring 2017, 2018*, 2019, 2020, 2021*.
YMF100 Introduction to mathematics and physics 1 (10 ECTS)
Offered in the first semester of the bachelor’s degree in electrical engineering (Vocational path / Y-vei). Concepts from pre-calculus and calculus. Numbers, algebra, equations and inequalities. Functions and second order expressions. Logarithms with base 10 and base e. Limits and asymptotes, derivatives, analysis of extrema for functions of one variable. Sequences and series. Physics: primarily movement and force. Full description: https://www.uis.no/en/course/YMF100_1
Autumn 2013.
Introduction to mathematics and physics 2 (YMF110, 10 ECTS)
Offered in the second semester of the bachelor’s degree in electrical engineering (Vocational path / Y-vei). Concepts from calculus. Trigonometric functions. Vectors in 2D and 3D. Integral calculus and methods such as integration by parts and integration by the inverse chain rule. Practical applications of integrals. Probability. Physics: potential and kinetic energy, momentum, and more on force and movement in 2D. Full description: https://www.uis.no/en/course/YMF110_1
Spring 2014 and 2016.

 

*Years where I have been responsible for the course, but the lectures have been given by others.

Publications

Vitenskapelige publikasjoner

Haus, Eivind Sandve; Drengstig, Tormod; Thorsen, Kristian

(2023)

Structural identifiability of biomolecular controller motifs with and without flow measurements as model output.

PLoS Computational Biology.

ISSN 1553-734X.

Volum 19.

Hefte 8.

DOI: 10.1371/journal.pcbi.1011398

Uluseker, Cansu; Kaster, Krista Michelle; Thorsen, Kristian; Basiry, Daniel; Shobana, Sutha; Jain, Monika; Kumar, Gopalakrishnan; Kommedal, Roald; Pala-Ozkok, Ilke

(2021)

A Review on Occurrence and Spread of Antibiotic Resistance in Wastewaters and in Wastewater Treatment Plants: Mechanisms and Perspectives.

Frontiers in Microbiology.

ISSN 1664-302X.

Volum 12.

DOI: 10.3389/fmicb.2021.717809

Stokka, Svein Håvard; Kommedal, Roald; Thorsen, Kristian; Uluseker, Cansu

(2021)

An Individual-based Model for Simulating Antibiotic Resistance Spread in Bacterial Flocs in Wastewater Treatment Plants.

Linköping Electronic Conference Proceedings.

ISSN 1650-3686.

Hefte 185.

s.436-443.

DOI: 10.3384/ecp21185436

Stokka, Svein Håvard; Haus, Eivind Sandve; Fjeld, Gunhild; Drengstig, Tormod; Thorsen, Kristian

(2021)

A Model of Aerobic and Anaerobic Metabolism in Cancer Cells - Parameter Estimation, Simulation, and Comparison with Experimental Results.

Linköping Electronic Conference Proceedings.

ISSN 1650-3686.

Hefte 185.

s.465-472.

DOI: 10.3384/ecp21185465

Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter

(2019)

The effect of integral control in oscillatory and chaotic reaction kinetic networks.

Physica D : Non-linear phenomena.

ISSN 0167-2789.

Volum 393.

s.38-46.

DOI: 10.1016/j.physd.2019.01.002

Ruoff, Peter; Agafonov, Oleg; Tveit, Daniel Myklatun; Thorsen, Kristian; Drengstig, Tormod

(2019)

Homeostatic controllers compensating for growth and perturbations.

PLOS ONE.

ISSN 1932-6203.

Volum 14.

Hefte 8.

DOI: 10.1371/journal.pone.0207831

Risvoll, Geir; Thorsen, Kristian; Ruoff, Peter; Drengstig, Tormod

(2017)

Variable setpoint as a relaxing component in physiological control.

Physiological Reports.

ISSN 2051-817X.

Volum 5.

Hefte 17.

DOI: 10.14814/phy2.13408

Stokka, Svein Håvard; Jakobsen, Kim Andre; Thorsen, Kristian; Drengstig, Tormod

(2017)

Physiological based Modeling and Control of an Industrial Tank Process.

Linköping Electronic Conference Proceedings.

ISSN 1650-3686.

s.284-291.

DOI: 10.3384/ecp17138

Fjeld, Gunhild; Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter

(2017)

Performance of Homeostatic Controller Motifs Dealing with Perturbations of Rapid Growth and Depletion.

Journal of Physical Chemistry B.

ISSN 1520-6106.

Volum 121.

Hefte 25.

s.6097-6107.

DOI: 10.1021/acs.jpcb.7b01989

Tveit, Daniel Myklatun; Thorsen, Kristian

(2017)

Passivity-based analysis of biochemical networks displaying homeostasis.

Linköping Electronic Conference Proceedings.

ISSN 1650-3686.

s.108-113.

DOI: 10.3384/ecp17138108

Agafonov, Oleg; Selstø, Christina Helen; Thorsen, Kristian; Xu, Xiang Ming; Drengstig, Tormod; Ruoff, Peter

(2016)

The organization of controller motifs leading to robust plant iron homeostasis.

PLOS ONE.

ISSN 1932-6203.

Volum 11.

Hefte 1.

DOI: 10.1371/journal.pone.0147120

Thorsen, Kristian; Risvoll, Geir; Tveit, Daniel Myklatun; Ruoff, Peter; Drengstig, Tormod

(2016)

Tuning of Physiological Controller Motifs. I: Proceedings of the 9th EUROSIM Congress on Modelling and Simulation Oulu, Finland 12-16 September 2016.

IEEE conference proceedings.

ISBN 978-1-5090-4119-0.

s.28-33.

DOI: 10.1109/EUROSIM.2016.174

Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter

(2014)

Transepithelial glucose transport and Na+/K+ homeostasis in enterocytes: an integrative model.

American Journal of Physiology - Cell Physiology.

ISSN 0363-6143.

Volum 307.

Hefte 4.

s.C320-C337.

DOI: 10.1152/ajpcell.00068.2013

Thorsen, Kristian; Agafonov, Oleg; Selstø, Christina Helen; Jolma, Ingunn Westvik; Ni, Xiaoyu; Drengstig, Tormod; Ruoff, Peter

(2014)

Robust Concentration and Frequency Control in Oscillatory Homeostats.

PLOS ONE.

ISSN 1932-6203.

Volum 9.

Hefte 9.

DOI: 10.1371/journal.pone.0107766

Thorsen, Kristian; Ruoff, Peter; Drengstig, Tormod

(2013)

Control theoretic properties of physiological controller motifs. I: Proceedings of the IEEE International Conference on System Science and Engineering, ICSSE 2013.

IEEE conference proceedings.

ISBN 978-1-4799-0007-7.

s.165-170.

DOI: 10.1109/icsse.2013.6614653

Drengstig, Tormod; Ni, Xiaoyu; Thorsen, Kristian; Jolma, Ingunn Westvik; Ruoff, Peter

(2012)

Robust Adaptation and Homeostasis by Autocatalysis.

Journal of Physical Chemistry B.

ISSN 1520-6106.

Volum 116.

Hefte 18.

s.5355-5363.

DOI: 10.1021/jp3004568

Drengstig, Tormod; Jolma, Ingunn Westvik; Ni, Xiaoyu; Thorsen, Kristian; Xu, Xiang Ming; Ruoff, Peter

(2012)

A Basic Set of Homeostatic Controller Motifs.

Biophysical Journal.

ISSN 0006-3495.

Volum 103.

Hefte 9.

s.2000-2010.

DOI: 10.1016/j.bpj.2012.09.033

Bøker og kapitler

Fjeld, Gunhild

(2020)

A systems biology approach to cellular homeostasis, volume changes and regulation of metabolism.

Universitetet i Stavanger.

ISBN 978-82-7644-916-7.

Hefte 509.

Tveit, Daniel Myklatun

(2020)

Structural Properties of Biological Integral Feedback Motifs.

Universitetet i Stavanger.

ISBN 978-82-7644-951-8.

Hefte 544.

Thorsen, Kristian

(2015)

Controller Motifs for Homeostatic Regulation and Their Applications in Biological Systems.

Universitetet i Stavanger.

ISBN 978-82-7644-628-9.

Hefte 276.

Formidling

Stokka, Svein Håvard; Kommedal, Roald; Thorsen, Kristian; Uluseker, Cansu

(2021)

An Individual-based Model for Simulating Antibiotic Resistance Spread in Bacterial Flocs in Wastewater Treatment Plants.

SIMS EUROSIM 2021 Conference on Modelling and Simulation - The 62nd International Conference of Scandinavian Simulation Society ;

2021-09-21 - 2021-09-23.

Stokka, Svein Håvard; Haus, Eivind Sandve; Fjeld, Gunhild; Drengstig, Tormod; Thorsen, Kristian

(2021)

A Model of Aerobic and Anaerobic Metabolism in Cancer Cells - Parameter Estimation, Simulation, and Comparison with Experimental Results.

SIMS EUROSIM 2021 Conference on Modelling and Simulation - The 62nd International Conference of Scandinavian Simulation Society;

2021-09-21 - 2021-09-23.

Thorsen, Kristian

(2020)

The WastewaterAMR Project - Spread of Antibiotic Resistance in Wastewater Treatment Plants.

Regional meeting Digital Life Norway;

2020-02-03.

Thorsen, Kristian; Kommedal, Roald; Lood, Rolf

(2020)

Wastewater treatment plants as critical reservoirs for resistance genes - Summary of JPI-EC-AMR JTC 2016 project: Gene-gas .

JPIAMR Online workshop: Interventions to reduce the development and transmission of AMR;

2020-09-03 - 2020-09-04.

Thorsen, Kristian; Davidson, Matthew

(2020)

Wastewater-AMR -- et partnerprosjekt i Senter for Digitalt Liv Norge.

Thorsen, Kristian; Grønnestad, Kjetil S.; Braut, Knut; Øien, Stian

(2020)

Lade-naboene kjemper om Elbil Markedet.

Uluseker, Cansu; Kaster, Krista Michelle; Thorsen, Kristian; Kommedal, Roald

(2019)

Modeling Antimicrobial Resistance Gene Transfer in Wastewater Treatment Plants.

Control Engineering Concepts in Systems- and Synthetic Biology;

2019-05-20 - 2019-05-22.

Uluseker, Cansu; Kaster, Krista Michelle; Thorsen, Kristian; Kommedal, Roald

(2019)

Mechanism of Antibiotic Resistance Gene Spread in Wastewater Treatment Plants Using Activated Sludge.

4th International Conference on Alternative Fuels, Energy and Environment (ICAFEE 2019);

2019-10-18 - 2019-10-21.

Thorsen, Kristian

(2019)

Mathematical modeling of biological processes and biological cybernetics.

ARC Meeting 2019;

2019-02-21.

Løvås, Mari; Thorsen, Kristian

(2019)

Teknologiaften - How to motivate and inspire girls to a career in STEM fields?.

Breaking the Ceiling - Women in International Higher Education and STEM Fields;

2019-05-06 - 2019-05-10.

Tveit, Daniel Myklatun; Thorsen, Kristian; Drengstig, Tormod

(2019)

Modeling regulatory mechanisms behind sustained glucose uptake in growing cancer cells.

Control Engineering Concepts in Systems- and Synthetic Biology;

2019-05-20 - 2019-05-22.

Thorsen, Kristian

(2019)

Principles for feedback and control in biological systems. And a controller for increased copper tolerance in yeast.

Control Engineeering Concepts in Systems- and Synthetic Biology;

2019-05-20 - 2019-05-22.

Thorsen, Kristian

(2019)

Mathematical foundations for industrial robots.

The Wide World of Maths lecture series;

2019-08-28.

Uluseker, Cansu; Basiry, Daniel; Stokka, Svein Håvard; Kaster, Krista Michelle; Thorsen, Kristian; Kommedal, Roald

(2019)

Modelling Antibiotic Resistance Gene Spread in Wastewater Treatment Plants.

JPI-AMR Meeting;

2019-12-05.

Uluseker, Cansu; Basiry, Daniel; Stokka, Svein Håvard; Kaster, Krista Michelle; Thorsen, Kristian; Kommedal, Roald

(2019)

Modelling Antibiotic Resistance Gene Spread in Wastewater Treatment Plants.

Collaboration Meeting;

2019-12-06.

Thorsen, Kristian

(2018)

Work at the UiS group for biological cybernetics: Building a controller for regulation of intracellular copper in yeast..

International Bioengineering Day UCMerced;

2018-04-04 - 2018-04-05.

Kommedal, Roald; Kumar, Gopalakrishnan; Kaster, Krista Michelle; Pala Ozkok, Ilke; Thorsen, Kristian

(2018)

A simple mathematical model for antimicrobial resistance gene transfer in wastewater treatment models.

3rd International Conference on Alternative Fuels, Energy and Environment (ICAFEE 2018) & 1st International Conference on Water Resources and Sustainability (ICWRS 2018);

2018-10-28 - 2018-10-31.

Ang, Jordan; Tveit, Daniel Myklatun; Fjeld, Gunhild; Drengstig, Tormod; Ruoff, Heinz Peter; McMillen, David R.; Thorsen, Kristian

(2018)

Reconciling principles for how to achieve feedback and control in biological systems.

18th Conference of the International Study Group for Systems Biology;

2018-09-24 - 2018-09-28.

Fjeld, Gunhild; Nordgård, Oddmund; Thorsen, Kristian

(2018)

Combining real time experimental data with a mathematical model to understand cancer cell metabolism.

18th conference of the International Study Group for Systems Biology (ISGSB);

2018-09-24 - 2018-09-28.

Thorsen, Kristian

(2018)

Mathematical foundations for industrial robots.

The future is now lecture series ;

2018-10-04 - .

Thorsen, Kristian

(2018)

How to achieve and understand feedback and control in biological systems.

MoBi2C Research Seminar;

2018-11-15 - .

Fjeld, Gunhild; Nordgård, Oddmund; Thorsen, Kristian

(2018)

Modeling the redirection of metabolic flux in cancer cells.

Cell Symposia Metabolites as Signaling Molecules;

2018-12-09 - 2018-12-11.

Stokka, Svein H.; Jakobsen, Kim A.; Thorsen, Kristian; Drengstig, Tormod

(2017)

Physiological based Modeling and Control of an Industrial Tank Process.

SIMS 2017;

2017-09-25 - 2017-09-27.

Tveit, Daniel Myklatun; Thorsen, Kristian

(2017)

Passivity-based analysis of biochemical networks displaying homeostasis.

The 58th Conference on Simulation and Modelling (SIMS 58);

2017-09-25 - 2017-09-27.

Thorsen, Kristian

(2016)

Kaosteori - deterministiske system med uventet og irregulær oppførsel..

ABB Robotics Bryne Foredragsserie;

2016-05-13.

Thorsen, Kristian; Risvoll, Geir; Tveit, Daniel Myklatun; Ruoff, Peter; Drengstig, Tormod

(2016)

Tuning of Physiological Controller Motifs.

Eurosim 2016;

2016-09-12 - 2016-09-16.

Thorsen, Kristian

(2016)

The tendency against change: control and regulation as a condition for life..

Article Binnale for elektronisk og ustabil kunst - Art Science and Cocktails;

2016-08-12.

Thorsen, Kristian; Risvoll, Geir; Mazumder, Mostafizur; McMillen, David R.

(2016)

A controller for regulation of intracellular copper in S. cerevisiae.

International Conference on Systems Biology ICSB2016;

2016-09-16 - 2016-09-20.

Thorsen, Kristian; Taraldsen, Lars; Andersen, Ina

(2015)

Automatisering - De mest utsatte ingeniørene: Derfor frykter de ikke automatiseringen.

Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter; Gundersen, Ina

(2015)

Nytt sykehus Ullandhaug - Jubler for plasseringen.

Agafonov, Oleg; Selstø, Christina Helen; Thorsen, Kristian; Xu, Xiang Ming; Drengstig, Tormod; Ruoff, Peter

(2015)

The Organization of Controller Motifs Leading to Robust Plant Iron Homeostasis.

The 26th International Conference on Arabidopsis Research;

2015-07-05 - 2015-07-09.

Thorsen, Kristian

(2015)

Building controller motifs to manipulate copper tolerance and homeostasis in S. cerevisiae..

CORE Research Seminar;

2015-06-05.

Thorsen, Kristian

(2013)

Kybernetikk og fysiologi - biokjemiske kontrollere.

Fagdagene 2013;

2013-03-12.

Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter

(2013)

Integrative modeling of glucose transport and homeostasis in enterocytes.

CSHL Meeting on Computational Cell Biology 2013;

2013-03-19 - 2013-03-22.

Drengstig, Tormod; Jolma, Ingunn Westvik; Thorsen, Kristian; Ruoff, Peter

(2013)

Fysiologiske reguleringsmekanismer.

Naturen.

ISSN 0028-0887.

Volum 137.

Hefte 4.

s.128-137.

Thorsen, Kristian; Drengstig, Tormod; Ruoff, Peter

(2012)

Modeling and simulation of intestinal nutrient uptake.

The 13th International Conference on Systems Biology;

2012-08-19 - 2012-08-23.

Thorsen, Kristian

(2012)

Cybernetics and physiology.

Servomøtet 2012;

2012-10-24 - 2012-10-25.