Hanne Røland Hagland

Førsteamanuensis i biokjemi

Hanne Røland Hagland

Kontakt

Telefon: 51831242

E-post: hanne.r.hagland@uis.no

Rom: I8 D-112

Sted: Måltidets og Havets hus, Innovasjonsparken I8

Organisasjonsenhet

Det teknisk-naturvitenskapelige fakultet

Institutt for kjemi, biovitenskap og miljøteknologi

Kort om meg

My research interest area is cancer cell metabolism. Cancer cells can be highly hetereogenous with regards to DNA mutations and gene expression, but still have a common ability to adapt and grow in challenging tumour growth environments. We are interested in studying the mitochondrial contribution to growth adaptation in cancer cells and how this influence cancer treatment response. We are working in close collaboration with clinicians in the field of translational oncology, adapting protocols to real patient samples to give more targeted treatment to cancer patients. Our lab facilities entails state of the art equipment for studying mitochondrial oxidative capacity in various cell models, as well as gene and protein expressions. 

I have been fortunate to have led a research network in health and technology here at UiS, where the aim was to facilitate meetings with people from different expertise areas to collaborate on solving health challenges. In our lab we currently have two 3D bioprinters and regular 3D printers to support our research with regards to extracellular matrix design with more advanced cell models (organoids, tumour spheroids) in our study of mitochondrial fitness in cancer. I am always interested in new collaborations and thrive in learning about new technologies to see how they can be used in our research to better tailor treatments for cancer disease. 

Publikasjoner

Vitenskapelige publikasjoner

Tidwell, Tia; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland

(2024)

Comparing in vitro cytotoxic drug sensitivity in colon and pancreatic cancer using 2D and 3D cell models: Contrasting viability and growth inhibition in clinically relevant dose and repeated drug cycles.

Cancer Medicine.

ISSN 2045-7634.

Volum 13.

DOI: 10.1002/cam4.7318

Adugna, Yosef Wakjira; Brüggemann, Heinrich; Hafnor, Erik; Djuv, Ane; Paulsen, Aksel; Hagland, Hanne Røland; Lemu, Hirpa G.

(2024)

Study on how 3D printer process parameters can be optimized for use in orthopedics fracture classification and surgical planning. I: Advances in Computational Mechanics and Applications.

Springer.

ISBN 978-3-031-49791-9.

s.143-154.

DOI: 10.1007/978-3-031-49791-9_10

Førde, Jan-Lukas; Alhourani, Abdelnour; Carey, Tian; Arbab, Adrees; Fladmark, Kari Espolin; Skrede, Silje; Mollnes, Tom Eirik; Herfindal, Lars; Hagland, Hanne Røland

(2024)

Impact of the Graphene Production Methods Sonication and Microfluidization on In Vitro and In Vivo Toxicity, Macrophage Response, and Complement Activation.

ACS Omega.

ISSN 2470-1343.

Volum 9.

Hefte 39.

DOI: 10.1021/acsomega.4c03189

Adugna, Yosef Wakjira; Lemu, Hirpa G.; Hagland, Hanne Røland

(2023)

Triply periodic minimal surfaces based functionally graded biomimetic scaffold fabrication via stereolithography.

IOP Conference Series: Materials Science and Engineering.

ISSN 1757-8981.

Volum 1294.

DOI: 10.1088/1757-899X/1294/1/012051

Carey, Tian; Alhourani, Abdelnour; Tian, Ruiyuan; Seyedin, Shayan; Arbab, Adrees; Maughan, Jack; Šiller, Lidija; Horvath, Dominik; Kelly, Adam; Kaur, Harneet; Caffrey, Eoin; Kim, Jong M.; Hagland, Hanne Røland; Coleman, Jonathan

(2022)

Cyclic production of biocompatible few-layer graphene ink with in-line shear-mixing for inkjet-printed electrodes and Li-ion energy storage.

npj 2D Materials and Applications.

Volum 6.

DOI: 10.1038/s41699-021-00279-0

Alhourani, Abdelnour; Førde, Jan-Lukas; Nasrollahzadeh, Mojdeh; Eichacker, Lutz Andreas; Herfindal, Lars; Hagland, Hanne Røland

(2022)

Graphene-based phenformin carriers for cancer cell treatment: a comparative study between oxidized and pegylated pristine graphene in human cells and zebrafish.

Nanoscale Advances.

Volum 4.

Hefte 6.

s.1668-1680.

DOI: 10.1039/d1na00778e

Tidwell, Tia R.; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland

(2022)

Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines.

Cancer & Metabolism.

ISSN 2049-3002.

Volum 10.

DOI: 10.1186/s40170-022-00285-w

Lea, Dordi; Watson, Martin Matthew Christian; Skaland, Ivar; Hagland, Hanne Røland; Lillesand, Melinda; Gudlaugsson, Einar; Søreide, Kjetil

(2021)

A template to quantify the location and density of CD3 + and CD8 + tumor-infiltrating lymphocytes in colon cancer by digital pathology on whole slides for an objective, standardized immune score assessment.

Cancer Immunology and Immunotherapy.

ISSN 0340-7004.

Volum 70.

s.2049-2057.

DOI: 10.1007/s00262-020-02834-y

Alhourani, Abdelnour; Tidwell, Tia; Bokil, Ansooya Avinash; Røsland, Gro V.; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne R.

(2021)

Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells.

Scientific Reports.

ISSN 2045-2322.

Volum 11.

Hefte 1.

s.1-10.

DOI: 10.1038/s41598-021-89861-6

Alhourani, Abdelnour; Førde, Jan-Lukas; Eichacker, Lutz Andreas; Herfindal, Lars; Hagland, Hanne Røland

(2021)

Improved pH-Responsive Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide.

ACS Omega.

ISSN 2470-1343.

Volum 6.

Hefte 38.

s.24619-24629.

DOI: 10.1021/acsomega.1c03283

Watson, Martin Matthew Christian; Lea, Dordi; Gudlaugsson, Einar; Skaland, Ivar; Hagland, Hanne Røland; Søreide, Kjetil

(2020)

Prevalence of PD‑L1 expression is associated with EMAST, density of peritumoral T‑cells and recurrence‑free survival in operable non‑metastatic colorectal cancer.

Cancer Immunology and Immunotherapy.

ISSN 0340-7004.

Volum 69.

s.1627-1637.

DOI: 10.1007/s00262-020-02573-0

Watson, Martin; Kanani, Arezo; Lea, Dordi; Khajavi, Ramesh Batol; Søreide, Jon Arne; Kørner, Hartwig; Hagland, Hanne Røland; Søreide, Kjetil

(2019)

Elevated Microsatellite Alterations at Selected Tetranucleotides (EMAST) in Colorectal Cancer is Associated with an Elderly, Frail Phenotype and Improved Recurrence-Free Survival.

Annals of Surgical Oncology.

ISSN 1068-9265.

DOI: 10.1245/s10434-019-08048-6

Talasila, Krishna Mukharji; Røsland, Gro Vatne; Hagland, Hanne Røland; Eskilsson, Eskil; Flønes, Irene Hana; Fritah, Sabrina; Azuaje, Francisco; Atai, Nadia A; Harter, Patrick N.; Mittelbronn, Michel; Andersen, Michael Borenste; Vareecal Joseph, Justin; Hossain, Jubayer; Vallar, Laurent; van Noorden, Cornelis J.F.; Niclou, Simone Pierrette; Thorsen, Frits; Tronstad, Karl Johan; Tzoulis, Charalampos; Bjerkvig, Rolf; Miletic, Hrvoje

(2017)

The angiogenic switch leads to a metabolic shift in human glioblastoma.

Neuro-Oncology.

ISSN 1522-8517.

Volum 19.

Hefte 3.

s.383-393.

DOI: 10.1093/neuonc/now175

Hagland, Hanne Røland; Lea, Dordi; Watson, Martin Matthew Christian; Søreide, Kjetil

(2017)

Correlation of blood T-cells to intratumoural density and location of CD3+ and CD8+ T-cells in colorectal cancer.

Anticancer Research.

ISSN 0250-7005.

Volum 37.

Hefte 2.

s.675-683.

DOI: 10.21873/anticanres.11363

Tidwell, Tia; Søreide, Kjetil; Hagland, Hanne Røland

(2017)

Aging, metabolism, and cancer development: From Peto's paradox to the Warburg effect.

Aging and Disease.

ISSN 2152-5250.

Volum 8.

Hefte 5.

s.662-676.

DOI: 10.14336/AD.2017.0713

Aunan, Jan Rune; Watson, Martin Matthew Christian; Hagland, Hanne; Søreide, Kjetil

(2016)

Molecular and biological hallmarks of ageing.

British Journal of Surgery.

ISSN 0007-1323.

Volum 103.

Hefte 2.

s.e29-e46.

DOI: 10.1002/bjs.10053

Søreide, Kjetil; Watson, Martin Matthew Christian; Hagland, Hanne Røland

(2016)

Deciphering the Molecular Code to Colorectal Liver Metastasis Biology Through Microsatellite Alterations and Allelic Loss: The Good, the Bad, and the Ugly.

Gastroenterology.

ISSN 0016-5085.

Volum 150.

Hefte 4.

s.811-814.

DOI: 10.1053/j.gastro.2016.02.060

Søreide, Kjetil; Watson, Martin Matthew Christian; Lea, Dordi; Nordgård, Oddmund; Søreide, Jon Arne; Hagland, Hanne Røland

(2016)

Assessment of clinically related outcomes and biomarker analysis for translational integration in colorectal cancer (ACROBATICC): Study protocol for a population-based, consecutive cohort of surgically treated colorectal cancers and resected colorectal liver metastasis.

Journal of Translational Medicine.

ISSN 1479-5876.

Volum 14:192.

DOI: 10.1186/s12967-016-0951-4

Watson, Martin Matthew Christian; Lea, Dordi; Rewcastle, Emma; Hagland, Hanne Røland; Søreide, Kjetil

(2016)

Elevated microsatellite alterations at selected tetranucleotides in early-stage colorectal cancers with and without high-frequency microsatellite instability: same, same but different?.

Cancer Medicine.

ISSN 2045-7634.

Volum 5.

Hefte 7.

s.1580-1587.

DOI: 10.1002/cam4.709

Hagland, Hanne Røland; Søreide, Kjetil

(2015)

Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways..

Cancer Letters.

ISSN 0304-3835.

Volum 356.

s.273-280.

DOI: 10.1016/j.canlet.2014.02.026

Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth; Hagland, Hanne; Kopperud, Reidun Kristin; Teigen, Knut; Schwede, Frank; Kleppe, Rune; Doskeland, Stein Ove

(2014)

Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.

PLOS ONE.

ISSN 1932-6203.

Volum 9.

Hefte 4.

DOI: 10.1371/journal.pone.0094926

Lea, Dordi; Håland, Sven; Hagland, Hanne; Søreide, Kjetil

(2014)

Accuracy of TNM staging in colorectal cancer: A review of current culprits, the modern role of morphology and stepping-stones for improvements in the molecular era.

Scandinavian Journal of Gastroenterology.

ISSN 0036-5521.

Volum 49.

Hefte 10.

s.1153-1163.

DOI: 10.3109/00365521.2014.950692

Hagland, Hanne; Hodneland, Linn I.; Burri, Lena; Nikolaisen, Julie; Berge, Rolf Kristian; Tronstad, Karl Johan

(2013)

Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA).

Biochemical and Biophysical Research Communications - BBRC.

ISSN 0006-291X.

Volum 430.

Hefte 2.

s.573-578.

DOI: 10.1016/j.bbrc.2012.11.111

Hagland, Hanne; Berg, Marianne; Jolma, Ingunn Westvik; Carlsen, Arne; Søreide, Kjetil

(2013)

Molecular Pathways and Cellular Metabolism in Colorectal Cancer.

Digestive Surgery.

ISSN 0253-4886.

Volum 30.

Hefte 1.

s.12-25.

DOI: 10.1159/000347166

Erikstein, Bjarte Skoe; Hagland, Hanne; Nikolaisen, Julie; Kulawiec, Marion; Singh, Keshav K.; Gjertsen, Bjørn Tore; Tronstad, Karl Johan

(2010)

Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment.

Journal of Cellular Biochemistry.

ISSN 0730-2312.

Volum 111.

Hefte 3.

s.574-584.

DOI: 10.1002/jcb.22741

Bredholt, Therese; Dimba, Elisabeth Anne Okumu; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell O.; Tronstad, Karl Johan; Johannessen, Anne Chr.; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore

(2009)

Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines.

Molecular Cancer.

ISSN 1476-4598.

Volum 8.

Hefte 101.

DOI: 10.1186/1476-4598-8-101

Petersen, Rasmus Kofoed; Madsen, Lise; Pedersen, Lone Møller; Hallenborg, Philip; Hagland, Hanne; Viste, Kristin; Doskeland, Stein Ove; Kristiansen, Karsten

(2008)

Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.

Molecular and Cellular Biology.

ISSN 0270-7306.

Volum 28.

Hefte 11.

s.3804-3816.

DOI: 10.1128/MCB.00709-07

Hagland, Hanne; Nikolaisen, Julie; Hodneland, Linn Iren; Gjertsen, Bjørn Tore; Bruserud, Øystein; Tronstad, Karl Johan

(2007)

Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling.

Expert opinion on therapeutic targets.

ISSN 1472-8222.

Volum 11.

s.1055-1069.

DOI: 10.1517/14728222.11.8.1055

Bøker og kapitler

Hagland, Hanne

(2012)

Cellular responses to metabolic stress – a study on the role of mitochondria in the crosstalk between cell metabolism and survival signalling.

Universitetet i Bergen.

ISBN 978-82-308-2092-6.

Hagland, Hanne; Selheim, Frode; Doskeland, Stein Ove

(2005)

Cyclic AMP dependent protein kinase (cAPK) and exchange protein directly activated by cAMP (Epac) signaling in Rat pheochromocytoma PC12 and Human Neuroblastma SH-SY5Y cell line.

Universitetet i Bergen.

Hagland, Hanne; Selheim, Frode; Keen, TJ; Skjærven, Kaja H; Christensen, Anne Elisabeth; Herfindal, Lars; Doskeland, Stein Ove

(2005)

The cAMP Receptors Epac and PKA synergize to induce PC12 cell neuritogenesis and to protect against apoptosis.

Medimond.

ISBN 978-88-7587-113-0.

Formidling

Adugna, Yosef Wakjira; Brüggemann, Heinrich; Hafnor, Erik; Djuv, Ane; Paulsen, Aksel; Hagland, Hanne Røland; Lemu, Hirpa Gelgele

(2023)

A framework for the visualization of femoral fractures from Imaging to 3D Print.

National Conference for Additive Manufacturing 2023;

2023-03-21 - 2023-03-22.

Naderi, Sheida; Hagland, Hanne Røland

(2023)

Mitochondrial fitness in pancreatic ductal adenocarcinomas.

CCBIO's 11th Annual Symposium (2023);

2023-05-08 - 2023-05-10.

Alhourani, Abdelnour; Tidwell, Tia; Bokil, Ansooya Avinash; Røsland, Gro Vatne; Tronstad, Karl Johan; Søreide, Kjetil; Hagland, Hanne Røland

(2022)

Author Correction: Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells (Scientific Reports, (2021), 11, 1, (10487), 10.1038/s41598-021-89861-6).

Scientific Reports.

ISSN 2045-2322.

Volum 12.

Hefte 1.

DOI: 10.1038/s41598-022-06177-9

Alsnes, Ingvild Vatten; Hagland, Hanne Røland; Janssen, Emiel; Dyrstad, Sindre Mikal; Vatland, Nina; Munkvik, Morten

(2022)

The Cognita model: group and activity-based learning .

AMEE Lyon2022;

2022-08-28 - 2022-08-31.

van der Giezen, Mark; Hagland, Hanne Røland; Berland, Unni

(2020)

På labben: UiS - Røland Hagland og van der Giezen.

forskningsdagene;

2020-09-16 - 2020-09-27.

Tidwell, Tia; Hagland, Hanne Røland; Røsland, Gro Vatne; Tronstad, Karl Johan

(2018)

Metabolic profiling of Colorectal cancer in 3D.

CCBIO konferanse;

2018-05-23 - 2018-05-24.

Bokil, Ansooya; Alhourani, Abdelnour; Hagland, Hanne Røland; Tidwell, Tia

(2018)

The metabolic profile of cancer cells play a major role in their response to metformin.

CCBIO konferanse;

2018-05-23 - 2018-05-24.

Akerjordet, Kristin; Hagland, Hanne Røland; Aas, Randi Wågø; Viksveen, Petter; Oftedal, Bjørg Frøysland; Laugaland, Kristin Alstveit; Wiig, Siri

(2018)

How to Educate Young People to work With Public Health and Better Aging.

Nordic Edge Expo;

2018-09-26.

Hagland, Hanne Røland; Tidwell, Tia

(2018)

Cancer cell migration and phenotype plasticity in the presence of a nutrient gradient.

Cell Symposia- Metabolites as signalling molecules ;

2018-12-09 - 2018-12-11.

Hagland, Hanne Røland

(2018)

Tverrfaglig samarbeid – hva må til? .

Ledersamling ved UiS;

2018-10-01.

Hagland, Hanne Røland; Tidwell, Tia

(2018)

Directed cell migration from a single spheroid culture in a small-molecule gradient.

Hagland, Hanne Røland

(2018)

Forskningsnettverk for helse og helseteknologi.

Helse Vest styringsgruppemøte;

2018-02-20.

Tidwell, Tia; Hagland, Hanne Røland

(2018)

Modeling the tumor microenvironment in a 3D microfluidic device with colorectal cancer spheroids.

Digital Life Norway Research School Annual Conference;

2018-05-30 - .

Hagland, Hanne Røland; Søreide, Kjetil; Lea, Dordi; Watson, Martin Matthew Christian

(2017)

Correlation of circulating T-cells in pre-operative blood to intratumoral density and location of CD3+ and CD8+ T-cells in colorectal cancer: a potential for an immunoscore by “liquid biopsy”? .

European Cancer Conference;

2017-01-27 - 2017-01-30.

Tidwell, Tia; Hagland, Hanne Røland

(2017)

Development of 3D cancer cell model to mimic in vivo growth conditions for discovery of metabolic biomarkers in cancer.

Life Science Symposium: Frontiers in Metabolism;

2017-10-24 - 2017-10-26.

Alhourani, Abdelnour; Tidwell, Tia; Bokil, Ansooya; Hagland, Hanne Røland

(2017)

The effects of metformin treatment in colorectal cancer cells  of opposing metabolic phenotype.

CCBIO;

2017-05-19 - 2017-05-21.

Hagland, Hanne Røland

(2016)

Kreftceller endrer metabolisme etter vekstbehov.

NKS møte;

2016-03-30.

Hagland, Hanne Røland

(2016)

Kreftbehandling ved bruk av immunterapi – gjennombruddet og begrensningene.

Fagdag for lærere i videregående skole;

2016-11-15.

Hagland, Hanne

(2015)

Cancer Cell Metabolism.

Breast Cancer meeting ;

2015-11-17 - 2015-11-18.

Nikolaisen, Julie; Hodneland Nilsson, Linn I.; Røland Hagland, Hanne; Koopman, Werner JH; Tronstad, Karl Johan

(2013)

Mitochondrial function, biogenesis and morphology in cellular stress.

Mitochondria, metabolic regulation and the biology of aging 2013;

2013-02-13 - 2013-02-16.

Nikolaisen, Julie; Nilsson Hodneland, Linn I.; Røland Hagland, Hanne; Koopman, Werner JH; Tronstad, Karl Johan

(2012)

Mitochondrial morphology and biogenesis in cellular stress.

Bioblast 2012: Conference on Mitochondrial Competence;

2012-12-10 - 2012-12-12.

Nilsson, L I H; Nikolaisen, Julie; Hagland, Hanne; Tronstad, Karl Johan

(2012)

A mitochondrial reporter system for studies on NRF-1/AMPK activity and regulation in viable cells.

Biochimica et Biophysica Acta - Bioenergetics.

ISSN 0005-2728.

Volum 1817.

s.S70-S70.

DOI: 10.1016/j.bbabio.2012.06.197

Hagland, Hanne; Nikolaisen, Julie; Hodneland, Linn I.; Tronstad, Karl Johan

(2008)

Mitochondrial function in cancer cell line models.

Biochimica et Biophysica Acta - Bioenergetics.

ISSN 0005-2728.

Volum 1777.

s.S41-S41.

DOI: 10.1016/j.bbabio.2008.05.164

Kunstnerisk produksjon

Nilsen, Mari Mæland; Hagland, Hanne Røland

(2020)

Nysgjerrig molekylærbiolog.